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Updated: Jul 18, 2025

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

Charting the Path: Navigating Embryonic Development to Potentially Safeguard against Congenital Heart Defects.

José Bragança^1,2,3,4, Rute Pinto^1,2, Bárbara Silva^1,2,3,5

¹Algarve Biomedical Center-Research Institute (ABC-RI), University of Algarve Campus Gambelas, 8005-139 Faro, Portugal.

Journal of Personalized Medicine

|August 25, 2023

Summary

Preventing congenital heart diseases (CHDs) may be possible through early embryonic interventions. Targeting faulty heart development with biomolecules or exosomes during gestation could reduce CHD severity and occurrence.

Keywords:

blastocyst cardiogenic signaling pathways congenital heart diseases exosome placenta and heart development secretomes stem cells

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Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

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Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

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Published on: October 7, 2016

Area of Science:

Developmental Biology
Cardiology
Regenerative Medicine

Background:

Congenital heart diseases (CHDs) arise from improper embryonic heart development.
Current treatments often involve palliative surgery after the heart has fully formed.
Early interventions during embryonic development show promise for improved outcomes.

Purpose of the Study:

To review key molecular and cellular processes in heart development.
To explore novel therapeutic strategies targeting early embryonic stages for CHD prevention.
To investigate non-surgical interventions for mitigating CHD severity.

Main Methods:

Review of existing research on cardiogenesis, signaling pathways, and transcription factors.
Analysis of potential therapeutic targets during embryonic development.
Exploration of biomolecule and exosome delivery for correcting faulty cardiac mechanisms.

Main Results:

Identified critical molecular and cellular events governing heart development.
Highlighted the potential of in utero fetal cardiac interventions.
Indicated that genetic/environmental factors causing CHDs might be amenable to alternative mechanisms.

Conclusions:

Early embryonic interventions, such as biomolecule or exosome delivery, offer a promising prophylactic approach to prevent CHDs.
Targeting cardiogenesis during early gestation could significantly reduce the incidence and severity of congenital heart defects.
Non-surgical strategies hold potential for improved CHD management and outcomes.