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Updated: Jul 18, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
One-Step, Catalyst-Free Formation of Phenol from Benzoic Acid Using Water Microdroplets
Yifan Meng1, Richard N Zare1, Elumalai Gnanamani2
1Department of Chemistry, Stanford University, Stanford, California 94305, United States.
Abstract:
Benzoic acid dissolved in water is electrosprayed (-4 kV) by using nitrogen gas at a pressure of 120 psi to form ∼10 μm diameter microdroplets. Analysis with mass spectrometry (MS) and tandem mass spectrometry (MS2) of the resulting microdroplets shows the direct formation of phenol via decarboxylation without any catalyst or added reagents. This process represents an ecofriendly, environmentally benign method for producing phenol and related aromatic alcohols from their corresponding aromatic acids. The mechanism of this transformation was unambiguously characterized using mass spectrometry, radical trapping, and 18O labeling.
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