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Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

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Related Experiment Video

Updated: Jun 5, 2026

Extraction and Analysis of Cortisol from Human and Monkey Hair
08:38

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Published on: January 24, 2014

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Dyadic Hair Cortisol Self-Collection Procedure.

Alison R Anderson, Ishika Mahajan, Jodi L Ford

    Nursing Research
    |August 25, 2023
    PubMed
    Summary
    This summary is machine-generated.

    This study outlines a procedure for at-home hair cortisol self-collection in dyads, including individuals with Alzheimer's disease and their caregivers. This method simplifies chronic stress assessment for vulnerable populations.

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    Area of Science:

    • Biomedical research
    • Psychology
    • Gerontology

    Background:

    • At-home specimen self-collection has increased due to the COVID-19 pandemic.
    • Hair cortisol analysis is crucial for assessing chronic stress in populations like Alzheimer's disease patients and their caregivers.
    • Scalp hair serves as a predictive biomarker for cumulative stress over several months.

    Purpose of the Study:

    • To present a study procedure for at-home scalp hair self-collection.
    • To enable cortisol concentration analysis in dyads of Alzheimer's patients and family caregivers.
    • To facilitate chronic stress assessment in vulnerable populations.

    Main Methods:

    • Participants provide informed electronic consent.
    • A self-collection kit is mailed to the home, with detailed video and print guides.
    • Hair samples are ideally collected during virtual meetings and mailed back to the lab.

    Main Results:

    • The study details a feasible procedure for at-home hair cortisol self-collection.
    • The described method is suitable for dyads, including those affected by Alzheimer's disease.
    • The procedure was developed considering the challenges faced by vulnerable populations.

    Conclusions:

    • At-home hair cortisol self-collection offers advantages like reduced participant burden.
    • This approach can enhance research participation, especially for individuals with mobility or environmental challenges.
    • The methodology is adaptable for various research objectives involving chronic stress assessment.