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Protein post-translational modifications: A key factor in colorectal cancer resistance mechanisms

Bo Bi1, Miaojuan Qiu2, Peng Liu1

  • 1Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Shenzhen, Guangdong, China; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Sun Yat-Sen University, Shenzhen, Guangdong, China.

Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms
|August 25, 2023
PubMed

Insights

Post-translational modifications (PTMs) are crucial in colorectal cancer (CRC) drug resistance. Understanding PTMs offers new therapeutic strategies to overcome resistance in CRC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Colorectal cancer (CRC) remains a leading cause of cancer mortality globally.
  • Drug resistance significantly hinders effective CRC treatment outcomes.
  • Post-translational modifications (PTMs) critically influence protein function and cellular processes, impacting cancer development.

Purpose of the Study:

  • To review recent advancements in understanding the role of PTMs in colorectal cancer resistance.
  • To explore the functional impact of PTMs on key signaling pathways and molecules involved in CRC resistance.
  • To identify potential therapeutic targets and strategies for overcoming drug resistance in CRC.

Main Methods:

  • Literature review of recent research on PTMs and CRC resistance.
  • Analysis of PTMs' impact on signaling pathways and drug development.
  • Summary of PTM enrichment methods and future research directions.

Main Results:

  • PTMs play a significant role in the development and progression of CRC drug resistance.
  • Specific PTMs affect signaling pathways crucial for CRC cell survival and drug evasion.
  • Current PTM enrichment methods and targeted therapies show promise but require further development.

Conclusions:

  • PTMs are critical regulators of CRC drug resistance, presenting viable therapeutic targets.
  • Further research into PTMs and development of PTM-targeted therapies are essential for improving CRC treatment.
  • Comprehensive PTM analysis methods are needed to fully elucidate their role in CRC resistance.
Keywords:
Colorectal cancerDrug resistancePTMsPost-translational modificationsProtein enrichment

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