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Three-Dimensional Bioprinting in Cardiovascular Disease: Current Status and Future Directions
Zhonghua Sun1,2, Jack Zhao3, Emily Leung3
1Discipline of Medical Radiation Science, Curtin Medical School, Curtin University, Perth, WA 6102, Australia.
Biomolecules
|August 26, 2023
Summary
Three-dimensional (3D) bioprinting offers advanced solutions for cardiovascular disease, enabling the creation of functional tissues and organs. This technology holds promise for repairing damaged heart tissues and blood vessels, advancing regenerative medicine.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Cardiovascular Science
Background:
- Three-dimensional (3D) printing is crucial in cardiovascular disease, providing accurate personalized models for education and surgical planning.
- 3D bioprinting advances this technology by enabling the printing of cellular components, tissues, and organs for cardiovascular applications.
Purpose of the Study:
- To review the current state and future potential of 3D bioprinting in cardiovascular disease.
- To focus on applications in cardiac tissues, vascular constructs, heart valves, and myocardium.
Main Methods:
- Review of recent advances in 3D bioprinting technologies.
- Analysis of applications in creating vascularized constructs, cardiac tissues, and heart valves.
Main Results:
- 3D bioprinting demonstrates potential for vascularization of large constructs with improved biocompatibility and stability.
- Emerging capabilities in printing functional cardiac tissues, vascular grafts, and heart valves.
Conclusions:
- 3D bioprinting presents significant opportunities for tissue and organ replacement in cardiovascular disease.
- Further research is needed to address limitations and fully realize the potential of this technology.
