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Retrovirus Life Cycles

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Related Experiment Video

Updated: Jul 18, 2025

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

Chronic Hepatitis B Infection: New Approaches towards Cure.

Mojisola Ogunnaike^1,2, Srijanee Das^1,2, Samiksha S Raut¹

¹Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.

|August 26, 2023

Summary

New long-acting treatments for chronic hepatitis B virus (HBV) infection show promise for improving patient adherence. These advancements include novel compounds and genome editing strategies targeting persistent viral DNA.

Keywords:

antivirals chronic hepatitis B gene editing hepatitis B virus

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Area of Science:

Hepatology and Virology
Drug Development and Delivery Systems

Background:

Chronic hepatitis B virus (HBV) infection is a major cause of cirrhosis and hepatocellular carcinoma.
Current nucleotide/nucleoside antiviral therapies suppress HBV replication but require lifelong daily adherence, which can be challenging for patients.

Purpose of the Study:

To review recent advances in long-acting formulations for HBV treatment and prevention.
To summarize novel compounds targeting the HBV life cycle and curative strategies.

Main Methods:

Review of current literature on long-acting antiviral formulations for HBV.
Summary of emerging compounds and genome editing technologies for HBV cure.

Main Results:

Long-acting formulations are being developed to potentially improve patient adherence to HBV therapy.
New compounds targeting distinct steps in the HBV life cycle are under investigation.
Curative strategies focus on eliminating covalently closed circular DNA and inactivating integrated viral DNA.

Conclusions:

Long-acting antivirals and genome editing present promising avenues for improved HBV management and potential cure.
These innovative approaches aim to overcome adherence challenges associated with current daily therapies.