Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.2K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic Architecture of Egg Production Traits in Chickens: A Systematic Review.

International journal of molecular sciences·2026
Same author

MicroRNA Biogenesis Pathway Gene Variants Are Associated with Prostate Cancer Susceptibility.

International journal of molecular sciences·2026
Same author

Long Non-Coding RNAs in Pathogenesis of Renal Cell Carcinoma: Epigenetic Regulation, Signaling Pathways, and Therapeutic Strategies.

International journal of molecular sciences·2026
Same author

Polystyrene nanoparticles promote endometrial cancer development through the ACSS2-mediated reprogramming of arachidonic acid metabolism.

Cell death discovery·2026
Same author

Management of urethral stricture: translating guidelines into clinical practice.

World journal of urology·2026
Same author

Genomic Insights into Abdominal and Intramuscular Fat Deposition in Chickens and Their Implications for Productivity Traits: A Systematic Review.

Animals : an open access journal from MDPI·2026

Related Experiment Video

Updated: Jul 18, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.6K

Prostate Cancer: Genetics, Epigenetics and the Need for Immunological Biomarkers.

Guzel Rafikova1, Irina Gilyazova1,2, Kadriia Enikeeva1

  • 1Institute of Urology and Clinical Oncology, Bashkir State Medical University, 450077 Ufa, Russia.

International Journal of Molecular Sciences
|August 26, 2023
PubMed
Summary

New immunological biomarkers from monocytes and macrophages show promise for improving prostate cancer (PCa) diagnosis and prognosis. These markers may link genetic risk, hormone metabolism, and immune response in PCa patients.

Keywords:
TAMscancer biomarkerscancer epigeneticcancer geneticsmonocytesprostate cancertumor microenvironment

More Related Videos

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

707
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

6.9K

Related Experiment Videos

Last Updated: Jul 18, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.6K
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

707
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

6.9K

Area of Science:

  • Oncology
  • Immunology
  • Biomarker Discovery

Background:

  • Prostate cancer (PCa) is a major global health concern with significant impact.
  • Current diagnostic markers like prostate-specific antigen (PSA) have limitations in sensitivity and specificity, leading to overdiagnosis and increased healthcare costs.
  • Genetic and epigenetic factors influence PCa development, but reliable clinical markers are lacking.

Purpose of the Study:

  • To review the potential of immunological biomarkers for enhancing prostate cancer diagnosis and prognosis.
  • To highlight recent advancements in identifying biomarkers from circulating monocytes and tumor-associated macrophages (TAMs).
  • To explore how these biomarkers can bridge the gap between genetic predisposition, hormonal metabolism, and immune responses in PCa.

Main Methods:

  • Literature review focusing on epidemiological data, genetic and epigenetic alterations in prostate cancer.
  • Analysis of recent research on immunological biomarkers, including circulating and intra-tumoral markers.
  • Emphasis on biomarkers derived from monocytes and TAMs.

Main Results:

  • Immunological biomarkers, particularly those from monocytes and TAMs, show potential for improved PCa diagnosis and prognosis.
  • These novel biomarkers may help establish connections between genetic factors, hormonal metabolism, and immune system activity in PCa.
  • Current genetic markers are not yet clinically reliable, and existing markers like PSA have limitations.

Conclusions:

  • Developing novel immunological biomarkers is crucial for advancing prostate cancer diagnosis, prognosis, and management.
  • Monocyte-derived and TAM-derived biomarkers represent a promising avenue for research.
  • These biomarkers could offer a more comprehensive understanding of PCa development and progression.