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Predicting Adverse Recanalization Therapy Outcomes in Acute Ischemic Stroke Patients Using Characteristic Gut
Ping-Song Chou1,2,3,4, Wei-Chun Hung5, I-Hsiao Yang6
1Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Microorganisms
|August 26, 2023
Summary
Gut bacteria composition in acute ischemic stroke (AIS) patients impacts recovery after recanalization therapy. Specific gut microbes correlate with neurological deficits and predict treatment outcomes, offering potential biomarkers.
Area of Science:
- Microbiology
- Neurology
- Gastroenterology
Background:
- Recanalization therapy is crucial for acute ischemic stroke (AIS) patients.
- Gut microbiota influences AIS pathology and outcomes.
- The link between gut microbiota and recanalization therapy outcomes is not well understood.
Purpose of the Study:
- Investigate gut microbiota features associated with neurological deficits in AIS patients post-recanalization.
- Determine if these microbiota features predict functional outcomes after therapy.
Main Methods:
- Collected fecal samples from 51 AIS patients undergoing recanalization therapy.
- Performed 16S rRNA gene sequencing (V3-V4) to analyze gut microbiota.
- Compared microbial diversity and composition between disability groups.
Main Results:
- Identified distinct gut microbiota profiles in patients with mild-to-moderate versus severe disability.
- Found specific bacteria (e.g., Bilophila, Butyricimonas) associated with better outcomes.
- Observed higher abundance of Bacteroides fragilis, Fusobacterium, and Parabacteroides gordonii in severe disability groups.
- Demonstrated that characteristic microbiota predicted adverse recanalization therapy outcomes.
Conclusions:
- Gut microbiota composition is significantly correlated with recanalization therapy outcomes in AIS patients.
- Specific gut microbial signatures may serve as promising biomarkers for early neurological deficits.
- Microbiota analysis can potentially predict recanalization therapy success in AIS.
