Mast cells in nerve end neuromas of mice

The volume density of mast cells was estimated in nerve end neuromas at various time-points after transection of the left sciatic nerve of 6-week-old mice. After an initial reduction in the amount of mast cells there was a steady increase with numerous cells in 6-month-old neuromas. The variation in amount of mast cells in the individual animals at each time-point was relatively large. Exposure of neuromas to mild trauma resulted in degranulation of mast cells. Possibly, these numerous mast cells, which can liberate their contents after very light touching, may influence the neuroma.