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Related Concept Videos

Drug Distribution: Plasma Protein Binding01:29

Drug Distribution: Plasma Protein Binding

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Drugs predominantly attach to plasma proteins, with only a small percentage remaining unbound. The unbound portion can be calculated as one minus the bound fraction. Acidic drugs form large, inactive complexes by reversibly binding to plasma albumin, which prevents them from diffusing across biological barriers. These drug-protein complexes act as reservoirs for the drugs. As the concentration of unbound drugs decreases, these complexes quickly dissociate to release the free drug, maintaining...
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Drug Biotransformation: Overview01:16

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Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
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Updated: Jul 18, 2025

Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process
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Plasma Modification Techniques for Natural Polymer-Based Drug Delivery Systems.

Pankaj Bhatt1,2, Vipin Kumar2, Vetriselvan Subramaniyan3,4

  • 1KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad 201206, Uttar Pradesh, India.

Pharmaceutics
|August 26, 2023
PubMed
Summary
This summary is machine-generated.

Plasma treatment enhances natural polymers for drug delivery by improving surface properties. This controllable technique offers better biocompatibility, drug loading, and release for advanced medical applications.

Keywords:
biocompatibilitydrug deliveryplasma diagnosticsplasma modificationplasma parameterssurface functionalizationsurface modification

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Engineering

Background:

  • Natural polymers are versatile for drug delivery but have surface limitations like poor wettability and adhesion.
  • Plasma treatment offers a solution by modifying natural polymer surfaces to improve their drug delivery capabilities.

Purpose of the Study:

  • To review recent advances in plasma modification of natural polymer-based drug delivery systems.
  • To focus on controllable plasma treatment techniques and their applications.

Main Methods:

  • Overview of plasma generation principles and process control.
  • Characterization techniques for plasma-treated natural polymer surfaces.
  • Discussion of applications in drug delivery.

Main Results:

  • Plasma treatment enhances natural polymer surface properties, improving wettability, adhesion, and drug loading/release.
  • Modified polymers show improved biocompatibility, controlled release, and potential for targeted delivery.
  • Controllable plasma techniques offer versatility in surface functionalization.

Conclusions:

  • Plasma modification is a powerful tool for optimizing natural polymers in drug delivery systems.
  • Controllable plasma treatments provide tailored surface properties for enhanced performance.
  • This approach holds significant potential for developing advanced drug delivery vehicles.