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Bioactive delivery systems based on starch and its derivatives: Assembly and application at different structural
Xiuping Liang1, Long Chen2, David Julian McClements3
1School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China.
Food Chemistry
|August 26, 2023
Summary
Starch and its derivatives are versatile carriers for bioactive substances, enabling controlled release across various structural levels. These natural polymers offer enhanced delivery for applications in food, materials, and medicine.
Area of Science:
- Biopolymer Science
- Materials Science
- Drug Delivery Systems
Background:
- Starch and modified starches are natural polymers with diverse structural levels.
- Starch-based materials are increasingly explored for advanced delivery systems.
- Controlled release of bioactive substances is crucial in various industries.
Purpose of the Study:
- To review the advancements in starch and its derivative-based delivery systems.
- To emphasize the role of starch's hierarchical structures in controlled release.
- To explore the potential of starch-based hydrogels.
Main Methods:
- Comprehensive literature review of starch structure and applications.
- Analysis of starch's hierarchical structures (molecular, helical, crystal, particle).
- Investigation of starch degradation products as carriers.
- Exploration of starch-based hydrogel formation.
Main Results:
- Starch degradation products (dextrins, branched starch) act as amphiphilic carriers.
- Starch-guest complexes at the helical level influence release mechanisms.
- Starch carriers at crystal/particle levels modulate release and enhance activity.
- Starch can form hydrogels for diverse applications.
Conclusions:
- Starch's hierarchical structures are key to controlled bioactive substance delivery.
- Starch derivatives offer versatile platforms for encapsulation and release.
- Starch-based hydrogels present significant potential in food, materials, and medicine.
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