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Metastatic NUT Carcinoma in a Child.

Daphne Fonseca1, Suseela Kodandapani2, Rayala Vikas Babu3

  • 1Department of Laboratory Medicine, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana State 500034 India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|August 28, 2023
PubMed
Summary

Nuclear protein in the testis (NUT) carcinoma is a rare cancer. Prompt recognition of NUT carcinoma is key for patient outcomes, especially with emerging BET inhibitor therapies.

Keywords:
Cervical lymph nodeMetastaticNUT carcinomaNasal septum

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Area of Science:

  • Oncology
  • Genetics
  • Pathology

Background:

  • Nuclear protein in the testis (NUT) carcinoma is a rare, aggressive malignancy.
  • It is characterized by NUT gene rearrangements on chromosome 15q14.
  • This cancer is often underdiagnosed, with limited data on its biology and management.

Purpose of the Study:

  • To report a case of pediatric NUT carcinoma.
  • To highlight diagnostic challenges and emphasize the importance of prompt recognition.

Main Methods:

  • Case report of a pediatric patient with a nasal septum mass and cervical lymphadenopathy.
  • Diagnostic imaging included CT and MRI of the paranasal sinuses (PNS).
  • Histopathology and immunohistochemistry (IHC) with NUT confirmed the diagnosis.

Main Results:

  • The patient presented with a soft tissue lesion involving the nasal septum and bilateral cervical lymphadenopathy.
  • Imaging revealed the extent of the tumor.
  • Histopathology and IHC confirmed metastatic NUT carcinoma.

Conclusions:

  • NUT carcinoma has a poor prognosis despite aggressive treatment.
  • Early and accurate diagnosis of NUT carcinoma is crucial for improving patient outcomes.
  • Emerging BET inhibitors offer new therapeutic avenues for NUT carcinoma.