Studies on the structural requirements for synthetic formyl peptide chemoattractants

Seven small molecular weight new peptides related to the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (CHO-Met-Leu-PheOH) have been prepared by classical peptide synthesis. Compounds were prepared to evaluate the requirements at the C-terminal Phe group/ Each analogue tested for its ability to induce lysosomal enzyme release from human neutrophils.