Infantile Fibrosarcoma of the Tongue Base

Ravi Meher1, Avani Jain2, Shramana Mandal3

  • 1Department of ENT, MAMC, New Delhi, India.

Insights

This case report details a rare infantile fibrosarcoma of the tongue base in a child. Wide local excision and histopathology confirmed the diagnosis, highlighting management complexities.

Area of Science:

  • Pediatric Oncology
  • Surgical Pathology

Background:

  • Infantile fibrosarcoma is a rare soft tissue tumor typically affecting extremities in infants and children.
  • Head and neck presentations, especially within the oral cavity, are exceptionally uncommon.

Purpose of the Study:

  • To report the first documented case of infantile fibrosarcoma originating from the tongue base.
  • To discuss the diagnostic and management challenges associated with this rare pediatric tumor.

Main Methods:

  • A comprehensive literature search was conducted to identify similar cases.
  • Diagnostic confirmation relied on histopathological examination of the excised tumor.
  • Surgical management involved wide local excision.

Main Results:

  • Histopathology confirmed infantile fibrosarcoma of the tongue base in a 9-year-old boy.
  • The tumor required wide local excision for treatment.
  • This represents the first reported instance of infantile fibrosarcoma specifically located at the tongue base.

Conclusions:

  • Infantile fibrosarcoma of the tongue base is an extremely rare pediatric entity.
  • Accurate diagnosis necessitates thorough histopathological evaluation.
  • Wide local excision, potentially combined with chemotherapy, is the recommended treatment approach.

Related Concept Videos

Tongue01:01

Tongue

The human tongue is a fascinating and complex organ, responsible for various essential functions such as swallowing, speech, and taste. It is also subject to various conditions and diseases. In this article, we delve into the anatomy of the tongue, its roles, and some common conditions that can affect it.
Anatomical Position in the Oral Cavity
The tongue is located within the oral cavity, also known as the mouth. It is attached to the floor of the mouth by a fold of mucous membrane called the...
1.0K
Assessment of the Mouth01:26

Assessment of the Mouth

A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
247
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.1K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K