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Pattern of Post COVID Fatigue in Elderly Patients
1Wrightington Wigan and Leigh NHS Trust, Lancs, UK.
Advances in Rehabilitation Science and Practice
|August 28, 2023
Summary
Long COVID (LC) incidence decreases in those over 70, challenging data bias explanations. This study explores aging factors for a distinct post-COVID fatigue phenotype in older adults.
Area of Science:
- Gerontology
- Immunology
- Infectious Diseases
Background:
- Long COVID (LC) incidence typically rises with age.
- A sharp decline in LC is observed in individuals over 70.
- Current explanations often cite data collection biases in this demographic.
Purpose of the Study:
- To investigate the pattern of Long COVID incidence in older adults.
- To explore alternative explanations for the reduced LC prevalence in those over 70.
- To characterize the phenotype of post-COVID fatigue in the elderly.
Main Methods:
- Analysis of local Long COVID patient data.
- Comparison of symptom reporting between younger and older cohorts.
- Exploration of immunological, metabolic, and epigenetic factors.
Main Results:
- Local data confirmed a lower incidence of LC, particularly fatigue, in individuals over 70.
- A distinct phenotype of post-COVID fatigue was observed, lacking typical post-exertional symptoms.
- This suggests factors beyond data collection bias may be involved.
Conclusions:
- The decline in Long COVID among the over-70s may not solely be due to reporting biases.
- Aging-related immunological, metabolic, or epigenetic changes could influence Long COVID presentation.
- Further research is needed to understand these age-specific mechanisms.
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