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lncRNA - Long Non-coding RNAs02:39

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HSP90 and Noncoding RNAs.

Qing Xu1,2,3,4, Haoduo Qiao1,2,3,4, Yunfei Xu1,2,3,4

  • 1Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, China.

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|August 28, 2023
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Heat shock protein 90 (HSP90) impacts noncoding RNA (ncRNA) synthesis and function. This review explores how ncRNAs also influence HSP90 activity, revealing a complex regulatory network.

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Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • Heat shock protein 90 (HSP90) are molecular chaperones crucial for protein folding and cellular homeostasis.
  • Noncoding RNAs (ncRNAs) regulate fundamental cellular processes including development, transcription, and metabolism.
  • ncRNAs interact with various molecules, including proteins, to exert their functions.

Purpose of the Study:

  • To systematically review the multifaceted interactions between HSP90 and ncRNAs.
  • To elucidate the impact of HSP90 on the synthesis and function of diverse ncRNAs.
  • To explore the reciprocal influence of ncRNAs on HSP90 activity.

Main Methods:

  • Literature review and systematic analysis of existing research on HSP90 and ncRNA interactions.
  • Integration of data on ncRNA biogenesis, function, and regulation by chaperones.
  • Analysis of studies detailing ncRNA-mediated modulation of HSP90.

Main Results:

  • HSP90 influences the synthesis, folding, and function of various ncRNAs.
  • ncRNAs directly and indirectly modulate HSP90 activity and client protein interactions.
  • A complex interplay exists where both HSP90 and ncRNAs regulate each other's biological roles.

Conclusions:

  • HSP90 plays a significant role in the lifecycle and function of ncRNAs.
  • ncRNAs contribute to the regulation of HSP90, impacting its chaperone activity.
  • Understanding this HSP90-ncRNA axis is vital for comprehending cellular regulation and stress responses.