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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: Jul 17, 2026

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
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Molecular chaperones in stroke-induced immunosuppression.

Haoduo Qiao1, Qing Xu1, Yunfei Xu1

  • 1Department of Neurosurgery, Xiangya Hospital, Central South University; Department of Pathophysiology, Xiangya School of Medicine, Central South University; Sepsis Translational Medicine Key Laboratory of Hunan Province; National Medicine Functional Experimental Teaching Center, Changsha, Hunan Province, China.

Neural Regeneration Research
|July 14, 2023
PubMed
Summary

Stroke impairs immune function, increasing infection risk. Molecular chaperones influence this immunosuppression, offering potential therapeutic targets to restore immune defense post-stroke.

Keywords:
Hsp70Hsp72Hsp90HspB5hypothalamic-pituitary-adrenal axismolecular chaperonesneuroprotectionstrokestroke-induced immunosuppressionsympathetic nervous system

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Area of Science:

  • Neuroimmunology
  • Molecular Biology
  • Proteostasis

Background:

  • Stroke-induced immunosuppression compromises the immune system, elevating risks of post-stroke infections and poor outcomes.
  • This condition is linked to central nervous system injury-induced immunosuppressive syndrome.
  • Molecular chaperones are crucial for protein homeostasis (proteostasis).

Purpose of the Study:

  • To review the role of molecular chaperones in stroke-induced immunosuppression.
  • To explore novel strategies for immune restoration after stroke.

Main Methods:

  • Literature review focusing on molecular chaperones and stroke-induced immunosuppression.
  • Analysis of chaperone interactions and pathway modulation.

Main Results:

  • Molecular chaperones significantly impact stroke-induced immunosuppression.
  • They modulate the activity of other chaperones, cochaperones, and related pathways.
  • Evidence suggests chaperones are key players in immune dysregulation post-stroke.

Conclusions:

  • Molecular chaperones are integral to the mechanisms of stroke-induced immunosuppression.
  • Targeting molecular chaperones presents a promising avenue for developing therapies to enhance immune defense in stroke patients.
  • Further research into chaperone pathways could lead to improved patient prognoses.