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Updated: Jul 17, 2025
08:18
Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
17.0K
[Skin aging-cellular senescence : What is the future?]
Karin Scharffetter-Kochanek1,2,3, Yongfang Wang4,5, Evgenia Makrantonaki5,6
1Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Deutschland. karin.scharffetter-kochanek@uniklinik-ulm.de.
Dermatologie (Heidelberg, Germany)
|August 28, 2023
Summary
Cellular senescence drives skin aging and related diseases. Therapies like senolytics and senomorphics can deplete senescent cells, promoting skin rejuvenation and organ function.
Area of Science:
- Gerontology and Regenerative Medicine
- Cellular Biology
- Dermatology
Context:
- Cellular senescence is a primary driver of skin and organ aging.
- Aging impairs the immune system's ability to clear senescent cells.
- Senescence is linked to numerous age-related diseases.
Purpose:
- To review senolytics, senomorphics, and cell-based therapies for skin aging.
- To explore their mechanisms and clinical potential.
- To assess their role in reducing cellular senescence.
Summary:
- Mitochondrial dysfunction and pro-aging pathways activate cellular senescence.
- This leads to dermal connective tissue degradation and suppressed skin stem cell niches.
- Senolytics and senomorphics aim to clear senescent cells.
Impact:
- Depleting senescent cells rejuvenates skin and organ function.
- Approved senolytics and senomorphics are available.
- These therapies offer potential for mitigating aging effects.
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