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Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
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Regulation of erythropoiesis: emerging concepts and therapeutic implications

Pu Tang1, Huaquan Wang1

  • 1Department of Hematology, General Hospital, Tianjin Medical University, Tianjin, People's Republic of China.

Hematology (Amsterdam, Netherlands)
|August 28, 2023
PubMed

The process of erythropoiesis is complex and involves the transfer of cells from the yolk sac to the fetal hepar and, ultimately, to the bone marrow during embryonic development. Within the bone marrow, erythroid progenitor cells undergo several stages to generate reticulocytes that enter the bloodstream. Erythropoiesis is regulated by various factors, with erythropoietin (EPO) synthesized by the kidney being the promoting factor and hepcidin synthesized by the hepar inhibiting iron mobilization. Transcription factors, such as GATA and KLF, also play a crucial role in erythropoiesis. Disruption of any of these factors can lead to abnormal erythropoiesis, resulting in red cell excess, red cell deficiency, or abnormal morphological function. This review provides a general description of erythropoiesis, as well as its regulation, highlighting the significance of understanding the process for the diagnosis and treatment of various hematological disorders.

Keywords:
Erythropoiesisanemiaembryonic erythropoiesiserythroferrone (ERFE)ferritinhuman erythropoietin (EPO)polycythemiatransferrin

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