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Published on: March 12, 2020
A new secondary metabolite from the marine-derived fungus Phomopsis lithocarpus FS508
Zi-Ling Tan1,2, Yu-Chan Chen2, Jian-Peng Zhang1,2
1School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Abstract:
Based on the One Strain-Many Compounds (OSMAC) strategy, the secondary metabolites of Phomopsis lithocarpus FS508 were investigated. As a result, a new secondary metabolite, 4-methoxy-3-[4-(acetyloxy)-3-methyl-2-butenyl]benzoic acid (1) as well as eleven known compounds were isolated from the fermentation product of the strain FS508. Their structures were determined by NMR, IR, UV, and MS spectroscopic data analyses. All the isolated compounds were evaluated for cytotoxic and anti-inflammatory activities. Among them, compounds 3 and 9 displayed potent cytotoxicity against HepG-2 cell line, and compounds 2, 3 and 12 showed significant anti-inflammatory activities.

