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Updated: Jul 17, 2025
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Base-promoted one-pot three-component desulphurization cross-coupling access to 4-cyanoimidazole
Jiangwei Wen1, Ting Zeng1, Kelu Yan1
1Key Laboratory of Green Natural Products and Pharmaceutical Intermediates in Colleges and Universities of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, P. R. China. wenjy@qfnu.edu.cn.
Abstract:
A novel, straightforward, and scalable base-mediated one-pot three-component desulphurization cross-coupling strategy is reported for the synthesis of 4-cyanoimidazole derivatives. Over 35 examples are provided and achieved yields exceeding 85%. Notably, the majority of these readily available compounds can be isolated through simple filtration, thereby circumventing the need for laborious column chromatography. Besides, the present protocol can be scaled up to 10 mmol with a yield of 87%, demonstrating promising potential for industrial applications.
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