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Updated: Jul 17, 2025

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
Cardiac Transthyretin Amyloidosis With Coincident Paget's Disease: A Case Report
Mohmmad H ALQattan1, Mukhtar A Alqadhi1, Abdullah A AlKhamis2
1Nuclear Medicine, Al-Ahsa Health Cluster, Al-Ahsa, SAU.
Abstract:
Cardiac amyloidosis is a condition that results from the accumulation of amyloid proteins in the extracellular matrix of the myocardium. The diagnosis of this disease was challenging as it lacked distinct clinical symptoms and required a biopsy to confirm amyloid deposition. However, there is increasing evidence of non-invasive diagnostic criteria for cardiac amyloidosis, especially for the transthyretin (TTR) type. We report a case of a patient with both cardiac transthyretin amyloidosis (ATTR) and Paget's disease, and we highlight the various radiological features of these two conditions using hybrid imaging techniques. In addition, we discuss the diagnostic imaging characteristics of ATTR cardiac amyloidosis.
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