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The Gap in Knowledge about Tapering Targeted Therapy being used as Monotherapy in Rheumatoid Arthritis: A Systematic
Charis F Meng1,2, Diviya A Rajesh1, Deanna P Jannat-Khat3,2
1Division of Rheumatology, Hospital for Special Surgery, New York, USA.
Current Rheumatology Reviews
|August 29, 2023
Summary
Tapering targeted monotherapy in rheumatoid arthritis (RA) is challenging, with low remission rates when stopping treatment. Dose reduction and early disease intervention may offer better outcomes for RA patients.
Area of Science:
- Rheumatology
- Immunology
- Pharmacology
Background:
- Biologic (b)-disease-modifying anti-rheumatic drugs (DMARDs) are used as monotherapy in up to 30% of RA patients.
- Interleukin (IL)-6 inhibitors and Janus kinase (JAK) inhibitors show efficacy in RA monotherapy.
- The feasibility of tapering targeted monotherapy in RA remains unexplored.
Conclusions:
- A significant gap exists in literature regarding tapering targeted monotherapy in RA.
- Stopping targeted monotherapy is unlikely to maintain disease control in RA.
- Dose reduction and early RA treatment strategies warrant further investigation for successful tapering.
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