Vitreous Hemorrhage in Pediatric Patients With X-Linked Retinoschisis: Characteristics and Outcomes

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Natasha F S da Cruz, Jesse D Sengillo, Hasenin Al-Khersan

    Ophthalmic Surgery, Lasers & Imaging Retina
    |August 29, 2023
    PubMed

    Insights

    Vitreous hemorrhage in X-linked retinoschisis (XLRS) often recurs in pediatric patients, despite favorable anatomical outcomes. Fluorescein angiography aids in assessing vascular changes in XLRS.

    Area of Science:

    • Ophthalmology
    • Genetics
    • Retinal Diseases

    Background:

    • X-linked retinoschisis (XLRS) is a genetic disorder affecting the retina.
    • Vitreous hemorrhage is a potential complication in pediatric patients with XLRS.

    Purpose of the Study:

    • To describe the management and outcomes of vitreous hemorrhage in children with XLRS.
    • To evaluate the utility of fluorescein angiography in XLRS patients with vitreous hemorrhage.

    Main Methods:

    • Retrospective case series of pediatric patients diagnosed with XLRS and vitreous hemorrhage.
    • Data collected from January 2000 to January 2022 at Bascom Palmer Eye Institute.
    • Included analysis of clinical presentation, interventions, and follow-up outcomes.

    Main Results:

    • Nine pediatric patients (12 eyes) with XLRS and vitreous hemorrhage were analyzed.
    • Peripheral capillary dropout was observed in 58.3% of eyes undergoing fluorescein angiography.
    • Fifty percent of eyes were managed conservatively, while 50% received interventions (intravitreal bevacizumab or surgery).
    • Recurrence of vitreous hemorrhage occurred in 58.3% of eyes during the 6-year mean follow-up.
    • All eyes achieved attached retinas and clear media at final follow-up.

    Conclusions:

    • Fluorescein angiography is valuable for evaluating the vascular phenotype in XLRS.
    • Pediatric patients with XLRS-related vitreous hemorrhage show good anatomical recovery.
    • Recurrent vitreous hemorrhage is a significant concern in this patient population.
    Abstract

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