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Updated: Jul 17, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Geographic social vulnerability is associated with the alpha diversity of the human microbiome
Nicole Farmer1, Katherine A Maki1, Jennifer J Barb1
1Translational Biobehavioral and Health Disparities Branch, National Institutes of Health, Clinical Center , Bethesda, Maryland, USA.
Importance:
As a risk factor for conditions related to the microbiome, understanding the role of SVI on microbiome diversity may assist in identifying public health implications for microbiome research. Here we found, using a sub-sample of the Human Microbiome Project phase 1 cohort, that SVI was linked to microbiome diversity across body sites and that SVI may influence race/ethnicity-based differences in diversity. Our findings, build on the current knowledge regarding the role of human geography in microbiome research, suggest that measures of geographic social vulnerability be considered as additional contextual factors when exploring microbiome alpha diversity.
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