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Signal-Enhanced Immunosensor-Based MOF-Derived ZrO2 Nanomaterials as Electrochemiluminescence Emitter for D-Dimer
Qingze Zeng1, Xue Dong1, Xiang Ren1
1Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, P. R. China.
This study introduces MOF-derived ZrO2 nanomaterials for stable anodic electrochemiluminescence (ECL) sensing. A novel immunosensor using ZrO2 and Cu-doped TiO2 enhances D-dimer detection with high sensitivity.
Area of Science:
- Electrochemiluminescence (ECL) sensing
- Nanomaterials science
- Biomedical diagnostics
Background:
- Metal oxide nanomaterials are promising for ECL sensing due to their stability and low toxicity.
- Research has predominantly explored cathodic ECL, with limited focus on anodic ECL properties of metal oxides.
Purpose of the Study:
- To develop novel metal oxide nanomaterials for stable anodic ECL signal generation.
- To create a sensitive immunosensor for D-dimer detection using these nanomaterials.
Main Methods:
- Synthesis of MOF-derived ZrO2 nanomaterials as luminophores.
- Development of an immunosensor incorporating ZrO2 and Cu-doped TiO2 (TiO2-Cu) as a coreaction accelerator.
- Utilizing a peptide ligand (NFC) for antibody immobilization.
Main Results:
- ZrO2 nanomaterials exhibited stable anodic ECL in tripropylamine (TPrA).
- The ZrO2/TiO2-Cu/TPrA system significantly enhanced ECL signals.
- The immunosensor achieved sensitive D-dimer detection with a linear range of 0.05-600 ng/mL and a detection limit of 21 pg/mL.
Conclusions:
- MOF-derived ZrO2 nanomaterials are effective for anodic ECL sensing.
- The developed immunosensor offers a highly sensitive and stable platform for D-dimer analysis.
- Cu-doped TiO2 acts as an efficient coreaction accelerator, boosting ECL signal intensity.
