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Sleep-Disordered Breathing and Prevalent Hypertension in Men With and Without HIV
Naresh M Punjabi1, Todd T Brown2, Alexandre R Abreu1
1Division of Pulmonary, Critical Care, and Sleep Medicine, Miller School of Medicine, University of Miami, Miami, FL.
Journal of Acquired Immune Deficiency Syndromes (1999)
|August 29, 2023
Summary
Sleep-disordered breathing (SDB) increases hypertension risk in men without HIV. However, in men with HIV, SDB does not significantly alter hypertension risk, suggesting differing predictors based on HIV status.
Area of Science:
- Cardiovascular Health
- Infectious Diseases
- Sleep Medicine
Background:
- Sleep-disordered breathing (SDB) is a recognized risk factor for hypertension.
- The relationship between HIV infection and hypertension is well-documented.
- The impact of HIV on the SDB-hypertension association requires further investigation.
Purpose of the Study:
- To determine if HIV infection modifies the association between SDB and hypertension.
- To investigate the independent and combined effects of HIV and SDB on hypertension risk.
- To identify differing predictors of hypertension based on HIV status.
Main Methods:
- Utilized in-home polysomnography to assess SDB in 779 men from the Multicenter AIDS Cohort Study.
- Defined hypertension based on blood pressure, medication use, or clinical diagnosis.
- Employed multivariable logistic regression to analyze associations between HIV, SDB, and hypertension.
Main Results:
- High prevalence of hypertension (53.8%) and SDB (82.8%) was observed.
- In men without SDB, HIV was independently associated with hypertension (OR: 3.05).
- In men without HIV, SDB was associated with hypertension (OR: 2.93); however, SDB did not significantly increase hypertension odds in men with HIV.
Conclusions:
- Hypertension predictors differ based on HIV status.
- SDB is linked to hypertension in men without HIV, but this association is not observed in men with HIV.
- Among men with HIV, SDB does not appear to influence the odds of developing hypertension.
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