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FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1

Dongyang Wang1,2, Xiaojing Zheng1, Lihong Chai1

  • 1Laboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an, China.

Elife
|August 29, 2023
PubMed

Insights

FAM76B protein inhibits inflammation by regulating hnRNPA2B1 translocation in traumatic brain injury and neurodegenerative diseases. This study reveals FAM76B

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Immunology

Background:

  • FAM76B is a nuclear speckle protein with an undefined role.
  • Inflammation is a key factor in traumatic brain injury (TBI) and neurodegenerative diseases.

Purpose of the Study:

  • To elucidate the function of FAM76B in inflammatory pathways.
  • To investigate FAM76B's role in TBI and neurodegenerative disease models.

Main Methods:

  • In vitro assays to assess NF-κB pathway inhibition.
  • In vivo studies using a mouse model of traumatic brain injury.
  • Analysis of human tissue samples from TBI and neurodegenerative disease patients.

Main Results:

  • FAM76B inhibits the NF-κB inflammatory pathway by affecting hnRNPA2B1 translocation.
  • FAM76B suppresses inflammation in a mouse model of TBI.
  • FAM76B interacts with hnRNPA2B1 in human tissues relevant to TBI and neurodegeneration.

Conclusions:

  • FAM76B plays a crucial role in regulating neuroinflammation.
  • FAM76B influences hnRNPA2B1 translocation, impacting inflammatory responses in TBI and neurodegenerative conditions.
  • This research provides novel insights into inflammation mechanisms.
Keywords:
FAM76BNF-κB pathwaycell biologyhnRNPA2B1immunologyinflammationmouseneuroinflammation

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