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Updated: Jul 17, 2025

Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology
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Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology

Published on: April 23, 2019

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Turbocharging synaptic transmission.

James E Rothman1, Kirill Grushin1, Manindra Bera1

  • 1Nanobiology Institute and Department of Cell Biology, Yale University, New Haven, CT, USA.

FEBS Letters
|August 29, 2023
PubMed
Summary

Synaptotagmin rings coordinate synaptic vesicle release by organizing SNAREpins. Peripheral SNAREpins, boosted by Complexin, accelerate neurotransmitter release for rapid synaptic transmission.

Keywords:
Munc13SNAREpinsintra-vesicular pressureneurotransmitter releasesynaptophysin

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