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Corticosteroids in COVID-19: pros and cons
Aymen Bahsoun1, Yeva Fakih1, Rana Zareef1,2
1Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Frontiers in Medicine
|August 30, 2023
Summary
Corticosteroids show promise in reducing COVID-19 severity. This review examines the molecular, pharmacologic, and clinical evidence for their use in treating coronavirus disease 2019 (COVID-19).
Area of Science:
- Infectious Diseases
- Pharmacology
- Clinical Medicine
Background:
- The COVID-19 pandemic presented a significant global healthcare challenge.
- Drug repurposing emerged as a strategy for rapid therapeutic development.
- Corticosteroids, known for anti-inflammatory effects, were investigated for COVID-19 treatment.
Purpose of the Study:
- To explore the role of corticosteroids in managing COVID-19.
- To review the existing molecular, pharmacologic, and clinical evidence supporting corticosteroid use.
Main Methods:
- Systematic review of clinical trials and scientific literature.
- Analysis of data on corticosteroid efficacy and safety in COVID-19 patients.
- Examination of the mechanisms of action of corticosteroids.
Main Results:
- Clinical trials indicate corticosteroids can decrease mortality and morbidity associated with COVID-19.
- Evidence suggests beneficial outcomes in specific patient populations.
- Variability in study design and quality necessitates careful interpretation of results.
Conclusions:
- Corticosteroids represent a key therapeutic option for COVID-19.
- Further research is needed to optimize their use and address limitations in existing studies.
- Understanding the molecular and clinical evidence is crucial for informed treatment decisions.
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