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Transcription termination factor ρ polymerizes under stress.
Bing Wang1, Nelly Said2, Tarek Hilal2,3
1Department of Microbiology and Center for RNA Biology, The Ohio State University, Columbus, OH, USA.
Biorxiv : the Preprint Server for Biology
|August 30, 2023
Summary
Bacterial RNA helicase Rho acts as a genome sentinel. Nucleotide binding controls Rho
Area of Science:
- Microbiology
- Molecular Biology
- Genetics
Background:
- Bacterial RNA helicase Rho is crucial for transcriptome quality control by terminating aberrant RNA synthesis.
- Understanding how Rho activity is regulated during stress and dormancy is essential for bacterial survival in natural environments.
Conclusions:
- Rho inactivation via hyper-oligomerization is a conserved regulatory mechanism across life.
- This study reveals a novel regulatory strategy for bacterial RNA processing and genome maintenance under stress.
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