Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

12
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
12
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

15
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
15
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

11
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
11
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

16
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
16
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

14
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
14
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

13
Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
13

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular evidence of Echinococcus canadensis (G6/G7) predominance in Mongolian livestock and its implications for control.

PLoS neglected tropical diseases·2026
Same author

Prevalence of sexual dysfunction and its association with fertility quality of life among infertile men in Henan, China.

Reproduction & fertility·2026
Same author

Genomic landscape and homologous recombination deficiency in malignant germ cell tumors reveals sex-specific therapeutic opportunities.

The Journal of pathology·2026
Same author

Few-shot real-time quantitative phase imaging based on lightweight networks.

Optics express·2026
Same author

Efficacy and safety of acupuncture for chronic spontaneous urticaria: a systematic review and meta-analysis.

Frontiers in medicine·2026
Same author

MRI and Meningioma Research: Hotspots and Trends via Bibliometric Analysis

Current medical imaging·2026

Related Experiment Video

Updated: Jul 17, 2025

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

818

Pediatric restrictive cardiomyopathy: a case report.

Hai-Long Dai1, Qing-Hui Wang2, Xuan Su2

  • 1Department of Cardiology, Key Laboratory of Cardiovascular Disease of Yunnan Province, Clinical Medicine Center for Cardiovascular Disease of Yunnan Province, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, P. R. China.

The Journal of International Medical Research
|August 30, 2023
PubMed
Summary

Restrictive cardiomyopathy (RCM) diagnosis in a child was confirmed via cardiac catheterization and genetic testing. Early anticoagulant use may prevent fatal thromboembolic events in pediatric RCM patients.

Keywords:
Restrictive cardiomyopathyTNNI3cardiac catheterizationcase reportgeneticsmutation

More Related Videos

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

24.7K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

15.9K

Related Experiment Videos

Last Updated: Jul 17, 2025

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

818
Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

24.7K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

15.9K

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Genetics
  • Rare Diseases

Background:

  • Restrictive cardiomyopathy (RCM) is a rare and diagnostically challenging condition in children.
  • Early diagnosis and management are crucial for improving outcomes in pediatric RCM.

Observation:

  • An 8-year-old girl presented with exertional dyspnea, biatrial enlargement on ECG/echocardiography, and normal pericardial thickness on MRI.
  • Cardiac catheterization revealed elevated filling pressures (LV EDP 20 mmHg, RV EDP 13 mmHg) and pulmonary hypertension (PASP 51 mmHg), with respiratory-dependent pressure changes indicative of RCM.

Findings:

  • Next-generation sequencing identified a heterozygous variant in the troponin I gene (TNNI3; c.574C>T), confirming the diagnosis of RCM.
  • Despite conservative management, the patient succumbed to heart failure and cerebral infarction within 12 months.

Implications:

  • This case highlights the importance of cardiac catheterization and genetic testing for diagnosing pediatric RCM.
  • Prophylactic anticoagulation should be considered to mitigate the risk of thromboembolic events in RCM patients.