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3D Printed Customizable Microsampling Devices for Neuroscience Applications.

Patrick M Pysz1,2, Julia K Hoskins3,4, Min Zou2,3,4

  • 1Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, United States.

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Summary

Advanced 3D printing, particularly two-photon polymerization, is enabling the creation of sophisticated in vivo brain devices for neuroscience research. These innovative microsampling devices offer enhanced capabilities for brain tissue manipulation and measurement.

Keywords:
3D printingadditive manufacturingmicrodialysismicrofabricationmicrofluidicsmicrosampling

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Neuroscientists require multifunctional in vivo brain devices for chemical/physical measurements and tissue manipulation (drug delivery, electrical stimulation, optogenetics).
  • Current device limitations hinder advanced neuroscience research and in vivo measurements.

Purpose of the Study:

  • To demonstrate the potential of 3D printing for creating next-generation in vivo brain devices.
  • To highlight the advantages and challenges of using 3D printing for microsampling devices.

Main Methods:

  • Exploration of 3D printing technologies, focusing on two-photon polymerization for nanoscale feature fabrication.
  • Analysis of 3D printing's application in creating both the core device and peripheral components.

Main Results:

  • 3D printing offers unprecedented flexibility and rapid processing for advanced neuroscience measurement devices.
  • Two-photon polymerization is identified as a key technology for fabricating microsampling devices with nm to μm feature sizes.
  • 3D printing facilitates novel improvements in microsampling device design and assembly.

Conclusions:

  • 3D printing is poised to revolutionize the development of in vivo brain devices for neuroscientists.
  • Microsampling devices fabricated via 3D printing represent a significant step towards next-generation neuroscience tools.