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Updated: Jul 17, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Lewis Base-assisted Arylation of Unsaturated Carbonyls
Miran Lemmerer1, Nuno Maulide1
1Faculty of Chemistry, Institute of Organic Chemistry, University of Vienna, Währinger Str. 38, 1090, Vienna, Austria.
Abstract:
The combination of Lewis bases with α,β-unsaturated carbonyls allows the in-situ generation of enolates without the need for strong Brønsted bases. Recently developed synthetic methods employ this approach for arylation followed by elimination of the Lewis base, regenerating the alkene. This strategy has been deployed for formal α- or β-C-H arylation in different contexts, namely (a) transition metal catalysis, (b) rearrangement reactions utilizing hypervalent main group elements and (c) organocatalysis. This concept article provides an overview of the developed strategies, highlighting and contextualizing their features.
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