Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Micronutrient status and growth outcomes in children with cow's milk allergy: beyond elimination diets.

Frontiers in nutrition·2026

Same author

Evidence-Based Clinical Recommendations for the Appropriate Use of Diagnostic Tests in Pediatric Allergology: Focus on Asthma, Rhinoconjunctivitis, and Keratoconjunctivitis Vernal.

Journal of clinical medicine·2026

Same author

Emerging Paediatric Uses of Dupilumab Beyond Approvals.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026

Same author

Hypertransaminasemia Is a Marker of Severity in Children Hospitalized for Influenza.

Influenza and other respiratory viruses·2026

Same author

Biological drugs for the treatment of children with atopic dermatitis.

Expert opinion on biological therapy·2026

Same author

Health inequities in pediatric anaphylaxis: A policy framework and call to action for equitable care from SIAIP allergy prevention commission.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026

Search research articles

Related Experiment Video

Updated: Jul 17, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Severe pediatric asthma endotypes: current limits and future perspectives.

Beatrice Andrenacci¹, Maria De Filippo^1,2, Martina Votto^1,2

¹Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

Expert Review of Respiratory Medicine

|August 30, 2023

Summary

This summary is machine-generated.

Pediatric severe therapy-resistant asthma (STRA) is complex and poorly understood. Research needs multicentric studies to differentiate endotypes and guide tailored treatments for better lifelong lung function.

Keywords:

Bronchoalveolar lavage bronchoscopy endotypes pediatrics severe asthma severe therapy resistant asthma

More Related Videos

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Published on: March 10, 2016

Related Experiment Videos

Last Updated: Jul 17, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Published on: March 10, 2016

Area of Science:

Pulmonology
Pediatric Allergy and Immunology
Asthma Research

Background:

Pediatric severe therapy-resistant asthma (STRA) is a rare, heterogeneous, and resource-intensive condition distinct from adult asthma.
The underlying pathogenesis of pediatric STRA remains incompletely understood, necessitating further investigation.

Purpose of the Study:

To review recent advancements in defining pediatric STRA endotypes over the past decade.
To discuss current research limitations and propose future research directions for pediatric STRA.

Main Methods:

Systematic review of English-written studies published in the last 10 years.
Focus on lung-specific techniques like bronchoalveolar lavage and endobronchial biopsy to define endotypes.

Main Results:

Identified heterogeneity within pediatric STRA, highlighting the inadequacy of a 'one-size-fits-all' approach.
Current research is limited by the lack of multicentric, longitudinal pediatric studies.

Conclusions:

Future research must focus on multicentric, longitudinal studies to differentiate prepubertal and pubertal STRA endotypes.
Early interventions targeting airway remodeling and precise characterization of inflammation are crucial for developing effective, tailored therapies and improving long-term lung function in pediatric STRA patients.