[Microcirculatory and hemostatic disorders in calculous pyelonephritis patients]

The state of microcirculation and the system of hemostasis were studied over time in 52 patients with chronic calculous pyelonephritis. Investigations were performed before operation, after 2-4 days, 5-7 days and on discharge. The patients were divided into 2 groups: with chronic pyelonephritis in the phase of active inflammation and with chronic pyelonephritis in the phase of remission. Marked disorders in the system of hemostasis characterized by hyperfibrinogenemia, thrombinemia, a decrease in the heparincofactor plasma activity, activation of platelet hemostasis, a decrease in CPa-dependent fibrinolysis were noted in the patients with calculous pyelonephritis in the phase of active inflammation. These shifts were combined with disorders in the microcirculatory system: intermittent blood flow and disseminated erythrocyte aggregation, a prolonged period of nuclide half-life in the intracutaneous depot. In the patients with calculous pyelonephritis in the remission phase shifts in the system of hemostasis were less noticeable, microcirculatory disorders were undetectable.