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Related Experiment Videos

The position effect in mice on day 14.

H von Domarus, T Louton, F Lange-Wühlisch

    Teratology
    |August 1, 1986
    PubMed
    Summary

    Embryonic position in the uterus bicornis impacts development. Embryos at the uterine horn ends were lighter, suggesting a positional effect on embryonic weight in mice.

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    Area of Science:

    • Reproductive Biology
    • Developmental Biology
    • Mammalian Reproduction

    Background:

    • Uterus bicornis, a congenital uterine anomaly, presents challenges in understanding embryonic development due to conflicting prior research.
    • The influence of uterine horn position on embryonic weight and development remains incompletely understood.

    Purpose of the Study:

    • To investigate the effect of embryonic position within the uterine horns on embryonic weight in a mouse model.
    • To quantitatively assess the relationship between placental position and embryonic development.

    Main Methods:

    • Utilized 503 embryos from 41 litters of NMRI mice on gestational day 14.
    • Determined relative embryonic position by measuring placental center distance to the cervix.
    • Embryos were weighed after fixation and removal of umbilical cords and membranes.

    Main Results:

    • Implantations were sparse at the extreme ovarian and cervical ends (approximately 10% of the uterine horn length).
    • A significant positional effect on embryonic weight was identified.
    • Embryos located at both the ovarian and cervical ends were lighter, with a mean weight difference less than 10% of the average.

    Conclusions:

    • Embryonic position within the uterine horns of a uterus bicornis significantly influences embryonic weight.
    • The findings provide quantitative evidence contrasting with some previous studies, highlighting the importance of positional factors in developmental outcomes.

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