Related Experiment Video
Updated: Jul 17, 2025

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
From Early Motor Ability to Global Cognitive Development 7 Years after Neonatal Arterial Ischemic Stroke
Antoine Giraud1,2,3, Pauline Garel3, Brian H Walsh4,5,6
1INSERM, U1059 SAINBIOSE, Université Jean Monnet, Saint-Étienne, France.
Abstract:
The developmental condition of children after neonatal arterial ischemic stroke (NAIS) is characterized by cognitive and motor impairments. We hypothesized that independent walking age would be a predictor of later global cognitive functioning in this population. Sixty-one children with an available independent walking age and full-scale intelligence quotient (IQ) score 7 years after NAIS were included in this study. Full-scale IQ was assessed using the fourth edition of the Wechsler Intelligence Scale for Children (WISC-IV). Independent walking age was negatively correlated with full-scale IQ score at 7 years of age (Pearson correlation coefficient of -0.27; 95% confidence interval from -0.48 to -0.01; p < 0.05). Early motor function is correlated with later global cognitive functioning in children after NAIS. Assessing and promoting early motor ability is essential in this population.

