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Updated: Jul 17, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Synthesis of Benzoselenophenes via TMSCN-Enabled Radical-Mediated Tandem Reaction Involving Enamides and Elemental
Zhenfeng Cheng1, Xiaodong Qiu1, Biao Xiong1
1School of Pharmacy, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226019, People's Republic of China.
Abstract:
This study presents a TMSCN-enabled tandem reaction involving enamides and elemental selenium to access a diverse array of benzoselenophenes. Notably, this methodology involves the direct 2-fold C(sp2)-H bond activation without the need for preinstalled halides or boronic acids as reaction handles. The protocol offers several noteworthy features, including the absence of transition metals and strong oxidants, high reaction efficiency, broad substrate scopes, and the use of stable elemental selenium as a selenium source.
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