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Cell-based Noninvasive Prenatal Testing (cbNIPT)-A Review on the Current Developments and Future Prospects.
Mohamad Ali Maktabi1, Liesbeth Vossaert2, Ignatia B Van den Veyver1,2
1Department of Obstetrics and Gynecology.
Clinical Obstetrics and Gynecology
|August 31, 2023
Summary
Scientists are exploring cell-based noninvasive prenatal testing (NIPT) as an alternative to cfDNA NIPT. Isolating rare fetal cells offers direct genetic analysis for diagnosing fetal conditions.
Area of Science:
- Reproductive medicine
- Genetics
- Molecular biology
Background:
- Current cell-free DNA (cfDNA)-based noninvasive prenatal testing (NIPT) has diagnostic limitations.
- Isolating intact fetal and trophoblast cells from maternal samples is a promising alternative.
- These rare cells provide a direct source of pure fetal genetic material.
Conclusions:
- Cell-based NIPT is a developing field with the potential to overcome limitations of cfDNA-based NIPT.
- Further research and technological advancements are crucial for its widespread clinical adoption.
- This approach offers a promising future for noninvasive prenatal diagnosis of fetal genetic conditions.
