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REM sleep deprivation induced by the modified multi-platform method has detrimental effects on memory: A systematic

Huaqiong Diao1, Yiming Li2, Wenjun Sun1

  • 1Department of Encephalopathy, Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China.

Behavioural Brain Research
|August 31, 2023
PubMed

Insights

The modified multi-platform method (MMPM) effectively models paradoxical sleep deprivation memory deficits in rodents. This meta-analysis confirms MMPM

Area of Science:

  • Neuroscience
  • Behavioral Science

Background:

  • Paradoxical sleep deprivation impairs memory in rodents.
  • The modified multi-platform method (MMPM) is a common tool for inducing these deficits.
  • Inconsistent MMPM protocols complicate interpretation of study findings.

Approach:

  • A meta-analysis was conducted on 50 studies using the MMPM in rats and mice.
  • The study assessed variations in MMPM protocols and their impact on memory performance.
  • Performance was evaluated using the Morris water maze (MWM), passive avoidance task, and radial arm water maze (RAWM).

Key Points:

  • MMPM significantly impaired spatial learning and memory in the MWM and passive avoidance task.
  • MMPM increased errors in the RAWM, indicating working memory deficits.
  • Mice showed greater deficits in the MWM, while rats exhibited more impairment in the passive avoidance task.
  • Specific MMPM timings (cross-learning, post-learning) exacerbated memory deficits in certain tasks.

Conclusions:

  • The MMPM is a reliable method for inducing memory deficits associated with paradoxical sleep deprivation in preclinical research.
  • Understanding MMPM protocol variations is crucial for consistent and reproducible findings in sleep and memory research.
Keywords:
MemoryMiceModified multi-platform methodRatsSleep deprivation

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