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Value of Combined Bone Morphogenetic Protein-2/7 Testing in the Assessment of Infected Preterm Labor
Insights
Elevated bone morphogenetic proteins (BMP-2 and BMP-7) are linked to infectious preterm birth (IPB) and inflammation. Their combined detection shows potential for diagnosing IPB and predicting adverse pregnancy outcomes.
Area of Science:
- Biochemistry
- Reproductive Medicine
- Immunology
Background:
- Infectious preterm birth (IPB) is a significant obstetric complication.
- Bone morphogenetic proteins (BMPs) play roles in inflammation and tissue repair.
- The specific role of BMP-2 and BMP-7 in IPB requires further elucidation.
Purpose of the Study:
- To investigate the clinical significance of serum bone morphogenetic protein-2 (BMP-2) and bone morphogenetic protein-7 (BMP-7) in infectious preterm birth (IPB).
- To evaluate the diagnostic and predictive value of BMP-2 and BMP-7 in IPB and associated adverse pregnancy outcomes.
- To explore the correlation between BMP-2, BMP-7, and inflammatory factors in pregnant women with IPB.
Main Methods:
- Serum levels of BMP-2, BMP-7, and inflammatory factors were quantified in 20 pregnant women with IPB and 20 controls.
- Receiver Operating Characteristic (ROC) curve analysis was used to assess diagnostic and predictive values.
- Pearson correlation coefficient was employed to determine relationships with inflammatory factors.
Main Results:
- Pregnant women with IPB exhibited significantly higher serum BMP-2 and BMP-7 levels compared to controls (P < .05).
- Joint detection of BMP-2 and BMP-7 demonstrated 80.00% sensitivity and 90.00% specificity for diagnosing IPB (P < .05).
- The combined BMP-2 and BMP-7 detection showed 100.0% sensitivity and 66.67% specificity for predicting adverse pregnancy outcomes in IPB (P < .05).
- A significant positive correlation was observed between BMP-2, BMP-7, and inflammatory factors in the IPB group (P < .05).
Conclusions:
- Serum BMP-2 and BMP-7 levels are elevated in infectious preterm birth.
- BMP-2 and BMP-7 are positively associated with inflammatory factor levels in IPB.
- The combined assessment of BMP-2 and BMP-7 holds promise for the evaluation of infectious preterm birth and adverse pregnancy outcomes.
Objective:
To analyze the clinical significance of bone morphogenetic protein-2 (BMP-2) and bone morphogenetic protein-7 (BMP-7), members of the bone morphogenetic protein family, in infectious preterm birth, to provide references for future prevention and management of IPB.
Methods:
The study participants were 20 pregnant women with IPB admitted to between January 2022 and January 2023 (research group) and 20 concurrent normal pregnancies (control group). Serum BMP2, BMP-7 inflammatory factors were quantified. Differences in BMP2 and BMP-7 were identified. The Receiver Operating Characteristic curve analyzed the evaluation value of BMP2 and BMP-7 on infectious preterm birth and adverse pregnancy outcomes in pregnant women, and Pearson correlation coefficient determined the correlation of the two with inflammatory factors levels.
Results:
The research group was higher in serum BMP2 and BMP-7 levels than control group (P < .05). The joint detection by BMP2 and BMP-7 had a sensitivity of 80.00% and a specificity of 90.00% in diagnosing infectious preterm birth (P < .05), and its sensitivity and specificity in predicting adverse pregnancy outcomes in infectious preterm birth pregnant women were 100.0% and 66.67%, respectively (P < .05). According to Pearson correlation coefficient analysis, there was an obvious positive relationship between BMP-2 and BMP-7 and inflammatory factors in research group (P < .05).
Conclusions:
BMP-2 and BMP-7 are elevated in IPB and are linked to inflammatory factor levels. Joint detection of BMP2 and BMP-7 shows promising potential for evaluating infectious preterm birth.
