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Computer-interpretable guidelines: electronic tools to enhance the utility of thyroid nodule clinical practice
Jeffrey R Garber1, Vivek Patkar2
1Atrius Health, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Frontiers in Endocrinology
|September 1, 2023
Summary
This study reviews clinical guidelines for thyroid nodule management. It introduces a computer interpretable guideline (CIG) concept and a web-based tool, the Thyroid Nodule Management App (TNAPP), for patient-specific recommendations.
Area of Science:
- Medical Informatics
- Clinical Decision Support
- Endocrinology
Background:
- Clinicians utilize narrative clinical guidelines and risk calculators for thyroid nodule evaluation and management.
- Existing resources present limitations in providing patient-specific recommendations at the point of care.
Purpose of the Study:
- To review the strengths and weaknesses of current thyroid nodule management resources.
- To introduce the concept of computer interpretable guidelines (CIGs).
- To describe the development and potential of a CIG-based tool for thyroid nodule management.
Main Methods:
- Review of existing clinical guidelines and risk calculators for thyroid nodules.
- Conceptualization and development of a novel computer interpretable guideline.
- Creation of an interactive web-based application (Thyroid Nodule Management App - TNAPP) based on the CIG concept.
Main Results:
- Narrative guidelines and risk calculators have inherent limitations.
- Computer interpretable guidelines offer a novel approach to transform guidelines into decision support tools.
- The TNAPP demonstrates the feasibility of a web-based CIG for thyroid nodule management, providing patient-specific recommendations.
Conclusions:
- Computer interpretable guidelines represent a significant advancement in clinical decision support.
- The TNAPP has the potential to improve thyroid nodule management by offering tailored recommendations.
- Widespread adaptation of CIGs may face barriers that require further consideration.

