Plant-derived nanovesicles: Further exploration of biomedical function and application potential

Area of Science:

• Biotechnology
• Nanomedicine
• Plant Science

Background:

• Extracellular vesicles (EVs) are key intercellular communicators, carrying functional biomolecules.
• Plant-derived nanovesicles (PNVs) offer advantages like safety, low cost, and low immunogenicity for therapeutic applications.

Purpose of the Study:

• To systematically review the biogenesis, isolation, characterization, and therapeutic potential of PNVs.
• To highlight PNVs as drug delivery carriers and therapeutic agents for various diseases.

Main Methods:

• Literature review of PNVs' biogenesis, isolation, and characterization.
• Analysis of PNVs' therapeutic applications, including anti-inflammatory, anticancer, wound healing, regeneration, and antiaging properties.
• Evaluation of PNVs' potential in treating liver disease and COVID-19.

Main Results:

• PNVs possess inherent therapeutic properties and can be utilized as drug delivery systems.
• PNVs demonstrate potential in anti-inflammatory, anticancer, wound healing, regenerative, and antiaging applications.
• PNVs show promise for treating liver disease and COVID-19, with low toxicity and immunogenicity.

Conclusions:

• PNVs represent a promising class of natural therapeutics with broad clinical potential.
• Further exploration of PNV functions is crucial for advancing their clinical translation.
• PNVs could facilitate a new framework for treating human diseases.