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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Treadmill perturbation-based balance training to prevent unrecovered falls in fall-prone older adults with and without cognitive impairment: protocol for the multi-center randomized controlled TRAIL study.

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Related Experiment Video

Updated: Jul 11, 2026

A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance
07:19

A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance

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[Reactive dynamic balance in the geriatric setting : Possibilities for evaluation and quantification in functionally

J Koschate1, T Stuckenschneider2, T Zieschang2

  • 1Fakultät VI - Medizin und Gesundheitswissenschaften, Abteilung Geriatrie, Carl von Ossietzky Universität Oldenburg, Ammerländer Heerstr. 140, 26129, Oldenburg, Deutschland. jessica.koschate@uni-oldenburg.de.

Zeitschrift Fur Gerontologie Und Geriatrie
|September 1, 2023
PubMed
Summary

Assessing reactive dynamic balance in older adults is crucial for fall risk. A new treadmill protocol helps quantify this balance, but standardized methods are needed for clinical use.

Keywords:
Accidental fallsGait adaptabilityGait analysisGait stabilityPerturbation treadmill

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Last Updated: Jul 11, 2026

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Area of Science:

  • Gerontology
  • Biomechanics
  • Gait Analysis

Context:

  • Falls in older adults often occur during walking due to gait instability.
  • Reactive dynamic balance assessment is vital for fall risk prediction and early intervention.
  • Current methods for evaluating balance reactions to gait perturbations are limited.

Purpose:

  • To critically discuss methods for gait perturbation and reaction pattern evaluation.
  • To present a diagnostic protocol for assessing reactive dynamic balance using treadmill-based gait perturbations.
  • To explore parameters for comprehensively mapping reactive dynamic balance.

Summary:

  • A protocol involving treadmill gait perturbations was developed and applied.
  • Gait speed was determined, followed by 9 types of disruptions over 4.5 minutes.
  • Evaluation included spatiotemporal parameters, margin of stability, and Lyapunov exponent.

Impact:

  • Reactive dynamic balance shows promise for quantifying fall risk in older individuals.
  • Comprehensive parameter evaluation is currently limited by a lack of established methods and references.
  • Developing a unified, sensitive method for reactive dynamic balance is essential for clinical fall risk assessment and training evaluation.