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Updated: Jul 17, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Scalable Electrochemical Decarboxylative Olefination Driven by Alternating Polarity
Alberto F Garrido-Castro1,2, Yuta Hioki1,3, Yoshifumi Kusumoto1
1Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Abstract:
A mild, scalable (kg) metal-free electrochemical decarboxylation of alkyl carboxylic acids to olefins is disclosed. Numerous applications are presented wherein this transformation can simplify alkene synthesis and provide alternative synthetic access to valuable olefins from simple carboxylic acid feedstocks. This robust method relies on alternating polarity to maintain the quality of the electrode surface and local pH, providing a deeper understanding of the Hofer-Moest process with unprecedented chemoselectivity.
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