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Dietary polyphenols and sleep modulation: Current evidence and perspectives
Jara Pérez-Jiménez1, Kaitha Agnant2, Rosa M Lamuela-Raventós3
1Dept. Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Madrid, Spain; CIBER of Diabetes and Associated Metabolic Disease (CIBERDEM), ISCIII, Madrid, Spain; Division of General Medicine and Center of Excellence for Sleep & Circadian Research, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Sleep Medicine Reviews
|September 2, 2023
Summary
Polyphenols, plant compounds with health benefits, show promise in improving sleep. Emerging research suggests dietary intake of polyphenols may positively impact sleep quality and architecture.
Area of Science:
- Nutritional Science
- Sleep Medicine
- Pharmacology
Background:
- Polyphenols are bioactive compounds found in plants, known for various health effects.
- Sleep disturbances are a growing public health concern, impacting overall well-being.
- Understanding dietary influences on sleep is crucial for developing effective interventions.
Purpose of the Study:
- To review and synthesize current scientific literature on the role of polyphenol intake in sleep modulation.
- To evaluate evidence from preclinical and human studies regarding polyphenol-diet and sleep outcomes.
- To identify potential mechanisms underlying the effects of polyphenols on sleep.
Main Methods:
- Systematic review of preclinical (animal) studies, human observational studies, and clinical intervention trials.
- Analysis of studies investigating the association between polyphenol consumption and sleep parameters.
- Identification and summary of proposed biological mechanisms of action.
Main Results:
- A significant majority of animal studies (26/28) reported beneficial effects of polyphenols on sleep architecture.
- Human observational studies (3/4) indicated a positive association between polyphenol intake and improved sleep.
- Clinical intervention studies (8/12) demonstrated beneficial effects of polyphenol intake on sleep, though with some inconsistencies.
Conclusions:
- Emerging evidence supports a beneficial role for polyphenol intake in modulating sleep.
- Potential mechanisms involve neurotransmitter regulation and gut-brain axis interactions.
- Further research with nutritional doses and targeted populations is recommended to confirm these effects.
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