Plasmonic nanosensors for pharmaceutical and biomedical analysis

Area of Science:

• Biotechnology and Biomedical Engineering
• Materials Science and Nanotechnology
• Analytical Chemistry

Background:

• Clinical biomarker detection demands high sensitivity, driving the need for advanced analytical platforms.
• Plasmonic nanomaterials have emerged as promising tools due to their unique optical properties.
• Existing methods face limitations in sensitivity and specificity for complex biomedical samples.

Purpose of the Study:

• To provide a comprehensive overview of plasmonic nanoplatforms for pharmaceutical and biomedical applications.
• To discuss the methodologies behind key plasmonic sensing techniques.
• To highlight recent advancements in plasmonic sensing for enhanced biomolecule and drug detection.

Main Methods:

• Review of surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) phenomena.
• Discussion of surface-enhanced Raman scattering (SERS), surface-enhanced infrared absorption (SEIRA), and surface-enhanced fluorescence (SEF) techniques.
• Analysis of plasmonic nanoplatform designs and their integration into sensing devices.

Main Results:

• Plasmonic sensing technologies based on SPR and LSPR offer high sensitivity and selectivity.
• Various plasmonic techniques (SERS, SEIRA, SEF) demonstrate significant potential for biomolecule and drug detection.
• Nanomaterial-based plasmonic nanosensors are effective for pharmaceutical and biomedical analysis.

Conclusions:

• Plasmonic nanoplatforms represent a significant advancement in sensitive and selective detection for biomedical and pharmaceutical fields.
• The reviewed techniques (SPR, LSPR, SERS, SEIRA, SEF) are crucial for developing next-generation diagnostic and analytical tools.
• Continued research in plasmonic nanomaterials will further enhance capabilities in single-molecule analysis and clinical diagnostics.