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Related Experiment Videos

Relationships between thyroid hormone and catecholamines in experimental trauma.

M Madsen, S Smeds, S Lennquist

    Acta Chirurgica Scandinavica
    |June 1, 1986
    PubMed
    Summary

    Administering triiodothyronine (T3) to severely injured pigs immediately after trauma increased catecholamines and mortality. T3 administration is not beneficial in the early "low T3 state" following major trauma.

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    Area of Science:

    • Endocrinology
    • Trauma Medicine
    • Physiology

    Background:

    • The "low T3 state" is observed in critically ill and injured patients.
    • Thyroid hormones (T3, T4) and catecholamines (adrenaline, noradrenaline) play crucial roles in metabolic regulation and stress response.
    • The interaction between thyroid hormones and catecholamines following severe trauma requires further elucidation.

    Purpose of the Study:

    • To investigate the relationship between thyroid hormones (T3, T4) and catecholamines (adrenaline, noradrenaline) in severely injured pigs.
    • To assess the potential therapeutic value of administered T3 in the acute phase of severe injury.
    • To explore the impact of T3 administration timing on catecholamine levels and survival.

    Main Methods:

    • Surgical preparation and high-energy missile trauma were inflicted on 36 pigs.
    • Triiodothyronine (T3) infusion was administered immediately before trauma, or 8 and 24 hours post-trauma in subgroups.
    • Serum catecholamine levels, hormone disappearance rates, and mortality were monitored.

    Main Results:

    • A significant correlation was found between catecholamine release and the disappearance rates of T3 and T4 (r=0.79 for adrenaline, r=0.64 for noradrenaline).
    • Immediate T3 administration pre-trauma led to elevated catecholamines, primarily noradrenaline, and high mortality (4/6), mimicking thyrotoxic crisis.
    • The catecholamine response to T3 was blunted at 8 hours and absent at 24 hours post-trauma.

    Conclusions:

    • Adrenaline release may be linked to the decrease in serum T3 and T4 concentrations after major trauma.
    • The findings support the hypothesis of T3 acting as a false neurotransmitter in this context.
    • Administering T3 during the initial phase of the "low T3 state" in severely injured patients is likely not beneficial and potentially harmful.

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