Related Experiment Video

Updated: Dec 9, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

574

Association between glycaemic outcome and BMI in Danish children with type 1 diabetes in 2000-2018: a nationwide

E H Ibfelt1, D Vistisen1, P Falberg Rønn1

  • 1Steno Diabetes Centre Copenhagen, Gentofte, Denmark.

Diabetic Medicine : a Journal of the British Diabetic Association
|September 12, 2020
PubMed

Insights

This study analyzed HbA1c and BMI trends in Danish children with type 1 diabetes. A non-linear association was found between HbA1c and BMI z-score, influenced by gender, age, and diabetes duration.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Diabetes Research

Background:

  • Type 1 diabetes (T1D) management requires monitoring glycemic control (HbA1c) and body mass index (BMI).
  • Understanding the interplay between HbA1c and BMI in pediatric T1D is crucial for long-term health outcomes.
  • The DanDiabKids registry provides a comprehensive dataset for longitudinal analysis in this population.

Observation:

  • Analysis of 6097 children with T1D from 2000-2018 in Denmark.
  • Median HbA1c was 65 mmol/mol (8.1%) and median BMI z-score was 0.85 in girls and 0.67 in boys.
  • BMI z-scores exhibited a non-linear relationship with HbA1c levels.

Findings:

  • The highest BMI z-scores were observed at intermediate HbA1c levels (approximately 60-70 mmol/mol).
  • This association was significantly modified by gender, age, and diabetes duration.
  • Severe hypoglycemia and insulin pump therapy showed a minor positive association with BMI z-score.

Implications:

  • Clinical management of pediatric T1D should consider the complex, non-linear relationship between glycemic control and BMI.
  • Individualized treatment strategies may be necessary, accounting for patient demographics and disease characteristics.
  • Further research into the mechanisms underlying these associations can inform preventative and therapeutic interventions.
Abstract

More Related Videos

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-1906:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.1K
Assessment of Child Anthropometry in a Large Epidemiologic Study09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

27.6K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.1K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.8K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.6K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.2K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.8K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
531